Detalhe da pesquisa
1.
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell;
184(8): 2167-2182.e22, 2021 04 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33811809
2.
Inhibitors of bromodomain and extra-terminal proteins for treating multiple human diseases.
Med Res Rev;
41(1): 223-245, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32926459
3.
Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial.
Cardiovasc Diabetol;
20(1): 125, 2021 06 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34158057
4.
RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease.
Mol Pharmacol;
92(6): 694-706, 2017 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28974538
5.
Inhibition of apolipoprotein A-I expression by TNF-alpha in HepG2 cells: requirement for c-jun.
J Cell Biochem;
115(2): 253-60, 2014 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24038215
6.
Induction of apolipoprotein A-I gene expression by black seed (Nigella sativa) extracts.
Pharm Biol;
52(9): 1119-27, 2014 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24635344
7.
Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.
Atherosclerosis;
364: 10-19, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36455344
8.
Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation.
Int Immunopharmacol;
117: 109929, 2023 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36857935
9.
The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation.
Transl Neurosci;
14(1): 20220332, 2023 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38222824
10.
Insulin mimetic effect of D-allulose on apolipoprotein A-I gene.
J Food Biochem;
46(2): e14064, 2022 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34984676
11.
Reduction in the risk of major adverse cardiovascular events with the BET protein inhibitor apabetalone in patients with recent acute coronary syndrome, type 2 diabetes, and moderate to high likelihood of non-alcoholic fatty liver disease.
Am J Prev Cardiol;
11: 100372, 2022 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36039183
12.
Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy.
Pharmacol Res Perspect;
10(3): e00949, 2022 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35417091
13.
Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators.
Biomed Pharmacother;
152: 113230, 2022 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35687908
14.
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.
Biomedicines;
9(4)2021 Apr 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33919584
15.
Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial.
J Alzheimers Dis;
83(4): 1703-1715, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34459400
16.
The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels.
Endocr Rev;
27(1): 2-16, 2006 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16243964
17.
Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease.
Cardiovasc Ther;
2020: 9397109, 2020.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32821285
18.
BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes.
Clin Epigenetics;
12(1): 166, 2020 11 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33172487
19.
Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators.
Biochim Biophys Acta;
1780(2): 264-73, 2008 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18082637
20.
Complement is an essential component of the immune response to adeno-associated virus vectors.
J Virol;
82(6): 2727-40, 2008 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18199646